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Contact Info

Email: casdean [at] rider.edu

Phone Number: 609-896-5155

Office Location: Lynch Adler Hall

Education

  • 1996-2001 Postdoctoral Fellow, Scripps Institution of Oceanography
  • 1991-1996 Ph.D. in Molecular and Cell Biology, Center of Marine Biotechnology; University of Maryland
  • 1987-1991 B.S. in Biology, Cook College, Rutgers University

Research Interests

My research interests primarily revolve around understanding the adaptive strategies employed by Archaea and Bacteria from extreme environments such as the deep-sea or hypersaline lakes. I am particularly interested in elucidating the molecular and genetic mechanisms used by these microbes to thrive under adverse ecological conditions.

Courses Taught

Genetics with Lab (BIO 265)
Microbiology with Lab (BIO 321)
Life Science: Genetics Emphasis (BIO 101)
Genetic Engineering and the Philosophy of Science (BHP 309)
Bioinformatics (BIO 416)

Funding

2011-2014 National Science Foundation. "RUI: Characterization of four cryptic circadian rhythm homologs in the haloarchaeon Haloferax volcanii" $394,729. Principle Investigator.

2007-2010 National Science Foundation. "RUI: Examination of the genetic mechanisms used to control the expression of salinity-regulated proteins in the archaeon Haloferax volcanii" $294,000. Principle Investigator.

2007-2014 Independent College Fund of NJ/Bristol Myers Squibb. Developing bioinformatics modules for the classroom. $35,000. Principle Investigator.

2003-2006 National Science Foundation. “RUI: Characterization of salinity regulated genes in the archaeal halophile, Haloferax volcanii” $255, 000. Principle Investigator.

1999-2002 National Science Foundation. "ToxR/S and fatty acid regulation in Photobacterium profundum strain SS9" (Dr. D. Bartlett, PI). $305,000. Co-investigator.

1999-2001 National Science Foundation. "Characterization of salt-senstive mutants in thearchaeal halophile, Haloferax volcanii" $75,000. Principle Investigator.

1996-1998 National Science Foundation Postdoctoral Research Fellow. $75,000.

Selected Publications

(undergraduate student authors are indicated by asterisk*)

  • Seth-Pasricha, M., S. Senn, L.E. Sanman, M. Bogyo, V. Nanda, K.A. Bidle and K.D. Bidle.  2018.
  • Catalytic linkage between caspase activity and stress-related protein complexes in Archaea. Environ. Microbiol. https://doi.org/10.1111/1462-2920.14456
  • Maniscalco, M., J. Nannen,V. Sodi*, G. Silver*, P. Lowrey, and K.A. Bidle. 2014. Light-dependent expression of four cryptic archaeal circadian gene homologs. Frontiers Microbiol. 5:79.
  • Seth-Pasricha, K.A. Bidle, and K. D. Bidle. 2013. Specificity of archaeal caspase activity in the extreme halophile Haloferax volcanii. Environ. Microbiol. Reports. 5: 263-271.
  • Boutaiba, S., H. Hacene, K.A. Bidle, and J. A. Maupin-Furlow. 2011. Microbial diversity of the hypersaline Sidi Ameur and Himalatt Salt Lakes of the Algerian Sahara. J. Arid Environ. 2011. DOI: 10.1016/j.jaridenv.2011.04.010.
  • Bidle, K. A., L. Haramaty, N. Baggett*, J. Nannen, and K. D. Bidle. 2010. Tantalizing evidence for caspase-like protein expression and activity in the cellular stress response of Archaea. Environ. Microbiol. 12:1161-1172.
  • Andriansolo, E. H., L. Haramaty, R. Rosario-Passapera, K. Bidle, E. White, C. Vetriani, P. Falkowski, and R. Lutz. 2009. Ammonificins A and B, hydroxyethyamine chroman derivatives from a cultured marine hydrothermal vent bacterium, Thermovibrio ammonificans. J. Nat. Prod. 72: 1216-1219.
  • Bidle, K. A., Kirkland, P. A., Nannen, J., and Maupin-Furlow, J. A. 2008. Proteomic analysis of Haloferax volcanii reveals salinity-mediated regulation of the stress responsive protein PspA. Microbiology 154: 1436-1443.
  • Bidle, K. A., T. E. Hanson, K. Howell, and J. Nannen. 2007. HMG-CoA reductase is regulated in response to salinity in the haloarchaeon Haloferax volcanii. Extremophiles 11: 49-55.
  • Bidle, K. A., W. Amadio, P. S. Oliveira, T. Paulish*, S. Hicks*, and C. Earnest*. 2005. A phylogenetic analysis of haloarchaea found within a solar saltern. BIOS 76: 89-96.
  • Bidle, K. A. 2003. Differential expression of genes influenced by changing salinity using RNA arbitrarily primed PCR in the archaeal halophile, Haloferax volcanii. Extremophiles 7: 1-7.
  • Bidle, K. A. and D. H. Bartlett. 2001. RNA arbitrarily primed PCR survey of genes regulated by ToxR in the deep-sea bacterium Photobacterium profundum strain SS9. J. Bacteriol. 183: 1688-1693.
  • Kastner, M., B. Carson, D. Bartlett, J. Jaeger, K. Bidle, and H. Jannasch. 2000. An in situ experiment of methane sequestration as gas hydrate, authigenic carbonate, and loss to the water column and/or atmosphere. In Gas Hydrates: Challenges for the Future. G. D. Holder and P. R. Bishnoi, eds. The New York Academy of Sciences, New York, NY. pp. 32-38.
  • Schreier, H. J., K. A. Robinson-Bidle, A. M. Romashko, and G. V. Patel. 1999. Heterologous expression in the Archaea: transcription from Pyrococcus furiosus gdh and mlrA promoters in Haloferax volcanii. Extremophiles. 3: 11-19.
  • Bartlett, D. H. and K. A. Bidle. 1999. Membrane-based adaptations of deep-sea piezophiles. In Enigmatic Microorganisms and Life in Extreme Environments. J. Seckbach, ed. Kluwer Academic Publishers, Dordrecht, The Netherlands. pp.501-512.
  • Bidle, K. A. and D. H. Bartlett. 1999. RecD function is required for high pressure growth in a deep-sea bacterium. J. Bacteriol. 181: 2330-2337.
  • Bidle, K. A., M. Kastner, and D. H. Bartlett. 1999. A phylogenetic analysis of microbial communities associated with methane hydrate containing marine fluids and sediments in the Cascadia Margin (ODP Site 892b). FEMS Microbiol. Lett. 177: 101-108.
  • Harwood, V. J., J. D. Denson, K. A. Robinson-Bidle, and H. J. Schreier. 1997. Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic Archaeon Pyrococcus furiosus. J. Bacteriol. 179: 3613-3618.
  • Robinson, K. A., D. A. Bartley, F. T. Robb, and H. J. Schreier. 1995. A gene from the hyperthermophile, Pyrococcus furiosus, whose deduced product is homologous to members of the prolyl oligopeptidase family of proteases. Gene 152: 103-106.
  • Robinson, K. A., F. T. Robb, and H. J. Schreier. 1995. Generation of subtraction probes for isolation of specific genes in thermophilic Archaea. In Archaea: A Laboratory Manual. F. T. Robb, K. R. Sowers, S. DasSarma, A. R. Place, H. J. Schreier, and E. M. Fleischmann (eds.) Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. Vol 3: pp. 119-123.
  • Robinson, K. A., F. T. Robb, and H. J. Schreier. 1994. Isolation of maltose-regulated genes from the hyperthermophilic archaeum Pyrococcus furiosus by subtractive hybridization. Gene 148: 137-141.
  • Robinson, K. A. and H. J. Schreier. 1994. Isolation, sequence, and characterization of the maltose-regulated mlrA gene from the hyperthermophilic archaeum Pyrococcus furiosus. Gene 151: 173-176.